Tune into this webinar, featuring three experts with unique perspectives, to learn about the progression of animal models, including discussions of improved treatment, successes of regulation, including APHIS regulations and the three Rs, and the current status of animal rights.

In this webinar, presenters will discuss best practices for data management and reporting, particularly when dealing with information security; archiving and disclosure of data analytics; and data management on teams that include collaborators around the globe.

Many people think that the Institutional Animal Care and Use Committee (IACUC) exists only to enforce rules and regulations. In reality, the IACUC, which is found at every university involved in federally funded animal research, can be a great resource to investigators by helping them determine the best methods for ensuring animal health and welfare while accomplishing the goals of a study.

Brain malformations, especially those affecting the cerebral cortex, are common causes of intellectual disability and epilepsy. Recent advances in genetics, imaging, and cell biology have substantially increased our knowledge of the mechanisms underlying cortical development and how it can go awry.

In this virtual conference, experts in the biology of astrocytes, oligodendrocytes, and microglia will share new insights into glial cells as key players in nervous system function. These insights come from work in a variety of animal species, ranging from fruit flies to humans.

Sheena Josselyn answers how women in neuroscience can balance family with a very demanding research and teaching career in this Q&A.

Although the majority of neurons in mammalian brains are generated during embryologic development, the production of new neurons continues throughout life in at least two brain regions in a process known as adult neurogenesis.

The development and maintenance of neural circuits in the brain are controlled by diverse signaling pathways.

Animal rights activist groups use a variety of crippling ploys to stunt research. Here’s a review of their tactics and what you can do to protect yourself and your research.

Fear generalization is a hallmark of anxiety disorders. Experimentally, fear generalization can be difficult to dissociate from its counterpart, fear discrimination. Here we use minimal threat learning procedures to reveal such a dissociation. We show that in Long Evans rats, an auditory threat cue predicting foot shock on 10% of trials produces a discriminated fear response that does not generalize to a neutral auditory cue. Even slightly higher foot shock probabilities (30% and 20%) produce fear generalization. AAV-mediated, caspase-3 deletion of ventral pallidum neurons abolishes fear generalization and reduces threat cue responding during extinction. The ventral pallidum’s contribution to fear generalization and extinction threat responding does not depend on inputs from the nucleus accumbens. The results demonstrate a minimal threat learning approach to dissociate fear discrimination from fear generalization, and a novel role for the ventral pallidum in generalizing and expressing fear. Significance ...