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1701 - 1710
of 52753 results
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Article Scientific ResearchOur lab focuses on the development and function of a relatively obscure brain region called the habenula.Nov 3, 2016
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Article Professional DevelopmentWhether it’s improving quality of life or embracing the latest technology, the promise of an advancing field is motivation for many neuroscientists to pursue and support meaningful research.Oct 27, 2016
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Article Professional DevelopmentAs I outlined in a previous article, the first step in applying to graduate school is finding programs that match your research interests is. The next step is weighing other important factors that could impact your experience.Oct 27, 2016
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Article TrainingDeveloping and assessing programs used to be a linear process because the training process was linear: graduate school, postdoctoral training, and academia.Oct 27, 2016
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Article OutreachAn elevator speech is one of your most important networking tools.Oct 25, 2016
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Article AdvocacyAs an assistant professor at Columbia University, founder of the Greater New York City Chapter of SfN (braiNY), and active advocate for science funding, Haung (Ho) Yu’s perspectives on the benefits of outreach are far reaching.Oct 20, 2016
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Video DiversityGet an inside look at how unconscious bias during the recruitment process can negatively impact female applicants and how to proactively change the approach in this Institució CERCA video.Oct 20, 2016
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Article OutreachAt the University of New England (UNE), we have invested in our community through both local outreach efforts in Maine and also through advancing the impact of global scientific and cultural exchange.Oct 18, 2016
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Article Career PathsWhen I started my career, I assumed that I would always stay in academia.Oct 18, 2016
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Journal ArticleChromatin regulation plays a crucial role in neocortical neurogenesis, and mutations in chromatin modifiers are linked to neurodevelopmental disorders. RBBP4 is a core subunit of several chromatin-modifying complexes; however, its functional role and genome-wide occupancy profile in the neocortical primordium are unknown. To address this, we performed RBBP4 knockdown using CRISPR/Cas9 on neocortical progenitors derived from mice of both sexes at embryonic age 12.5 during deep-layer neurogenesis. Our study demonstrates that downregulation of RBBP4 in the E12.5 neocortical progenitors reduced neuronal output, specifically affecting CTIP2-expressing neurons. We demonstrate that RBBP4 plays an essential role in regulating neocortical progenitor proliferation. However, overexpression of RBBP4 alone was not sufficient to regulate neuronal fate. Genome-wide occupancy analysis revealed that RBBP4 primarily binds to distal regulatory elements, and neuron differentiation is a significant GO biological pathway of RB...Nov 26, 2024














