It is widely believed that axons in the central nervous system of adult mammals do not regrow following injury. This failure is thought, at least in part, to underlie the limited recovery of function following injury to the brain or spinal cord. Some studies of fixed tissue have suggested that, counter to dogma, norepinephrine (NE) axons regrow following brain injury. Here, we have used in vivo two-photon microscopy in layer 1 of the primary somatosensory cortex in transgenic mice harboring a fluorophore selectively expressed in NE neurons. This protocol allowed us to explore the dynamic nature of NE axons following injury with the selective NE axon toxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). Following DSP4, NE axons were massively depleted and then slowly and partially recovered their density over a period of weeks. This regrowth was dominated by new axons entering the imaged volume. There was almost no contribution from local sprouting from spared NE axons. Regrown axons did not appear to ...

As he earns his PhD, Ian McLaughlin makes time to step beyond the bench to educate the public about the brain.

This resource was featured in the NeuroJobs Career Center. Visit today to search the world’s largest source of neuroscience opportunities. With different opportunities and environments in academia, industry, and government, how can neuroscientists determine the right career path for them? Understanding what to expect in each field can help you make informed choices that lead to satisfaction and success whether you are just starting out or transitioning later in your career. In this webinar, representatives from academia, industry, and government will showcase the unique characteristics of each workplace and share advice on what to consider when contemplating a career move based on their own transitions. Right after the panel discussion, head to the Neuronline community for a special live chat with the webinar speakers, where they will take your career path questions. This webinar and live chat are open to all SfN members. Not a member? Join or renew your membership today.

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