Next Generation Human Disease Models in Neuroscience

Organized by Lorenz Studer, MD and Marius Wernig, MD, PhD

September 27, 11 a.m.–5 p.m. EDT

Kristin Baldwin

Kristin Baldwin, PhD

Kristin Baldwin is a professor in the department of neuroscience at Scripps Research, where she is also an investigator at the Dorris Neuroscience Center, and an adjunct professor of neuroscience at the University of California, San Diego. Baldwin’s research interests lie at the intersection of molecular neurobiology, genomics, and stem cell biology/reprogramming. Her lab uses cloning, direct reprogramming, and genome editing to address questions of cellular diversity and genome stability in mice and humans. She received her BS in economics and zoology from Duke University and her PhD in immunology from Stanford University, and conducted postdoctoral work in neurobiology with Richard Axel at Columbia University.

Silvia Cappello

Silvia Cappello, PhD

Silvia Cappello is a research group leader at the Max Planck Institute of Psychiatry, in Munich, Germany. The major focus of her laboratory is to understand the basic molecular and cellular mechanisms regulating the development of the human brain. Cappello studied biotechnology at the University of Bologna, Italy, and carried out her PhD in the department of pharmacology at the University of Padua, Italy and in the laboratory of Magdalena Götz, at the Max Planck Institute of Neurobiology and the Helmholtz Center. As a postdoctoral fellow, she studied mechanisms regulating neurogenesis and neuronal migration with Magdalena Götz and in the laboratory of Richard Vallee at Columbia University.

Justin Ichida

Justin Ichida, PhD

Justin K. Ichida is an assistant professor of stem cell biology and regenerative medicine at the Keck School of Medicine at the University of Southern California. Ichida researches the etiology, pathogenesis, genetics, and treatment of neurodegenerative diseases, with a focus on amyotrophic lateral sclerosis (ALS). His work has garnered several awards, including a Pathway to Independence Award from the National Institutes of Health, the New York Stem Cell Foundation Innovator Award, and the Champion for a Cure Award from the ALS Association. He completed his PhD and postdoctoral studies at Harvard University.

Arnold Kriegstein

Arnold Kriegstein, MD, PhD

Arnold Kriegstein is the John Bowes Distinguished Professor in Stem Cell and Tissue Biology and founding director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at the University of California, San Francisco (UCSF), and a member of the National Academy of Medicine. Kriegstein received his BA from Yale University and his MD and PhD degrees from New York University. He has held academic appointments at Stanford University, Yale University, and Columbia University, joining the neurology department at UCSF in 2004. His research focuses on the way in which neural stem and progenitor cells in the embryonic brain produce neurons, and ways in which this information can be used for cell-based therapies to treat diseases of the nervous system.

Guo-li Ming

Guo-li Ming, MD, PhD

Guo-li Ming is currently Perelman Professor of Neuroscience and a member of Institute of Regenerative Medicine at the University of Pennsylvania School of Medicine. She completed her medical training in child and maternal care at Tongji Medical University, in China, earned her PhD from the University of California, San Diego, and completed her postdoctoral training at the Salk Institute for Biological Studies. The research in her laboratory centers on understanding the molecular mechanisms underlying neuronal development and its dysregulation using mouse systems and patient-derived induced pluripotent stem cells.

Hideyuki Okano

Hideyuki Okano, MD, PhD

Hideyuki Okano is a professor of physiology and dean of the Keio University School of Medicine. He also is a project leader of Japan’s Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) project. He received his MD in physiology and his PhD in molecular biology from Keio University, and completed postdoctoral work in the lab of Craig Montell at the Johns Hopkins University School of Medicine. His research focuses on regenerative medicine as it includes neural stem cells and induced pluripotent stem cells (iPSCs), spinal cord injury, developmental genetics, and RNA-binding proteins. Through his work he aims to establish and provide patient-specific iPSCs and genetically modified nonhuman primate models for neuroscience and to explore the pathogenic mechanisms of neurological and psychiatric disorders.

Lorenz Studer

Lorenz Studer, MD

Lorenz Studer is the director of the Center for Stem Cell Biology and a member of the developmental biology program at the Memorial Sloan Kettering Cancer Center. His lab has established many of the currently available techniques for turning pluripotent stem cells into the diverse cell types of the nervous system. His primary research interest is in regenerative medicine, and he leads a multidisciplinary consortium to pursue the clinical application of human stem cell-derived dopamine neurons for the treatment of Parkinson's disease.

Paul Tesar

Paul Tesar, PhD

Paul Tesar is the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at Case Western Reserve University (CWRU) School of Medicine, in the department of genetics and genome sciences. Tesar earned his BS from CWRU and his PhD from the University of Oxford. He joined the CWRU School of Medicine faculty in 2010 as a Mt. Sinai Health Care Foundation Scholar and has co-founded a Cleveland-based biotechnology company, Convelo Therapeutics, to discover and develop new therapies for disorders of myelin.

Marius Wernig

Marius Wernig, MD, PhD

Marius Wernig is an associate professor of pathology at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University. He graduated with an MD/PhD from the Technical University of Munich, where he trained in developmental genetics in the lab of Rudi Balling. After completing his residency in neuropathology and general pathology at the University of Bonn, he was a postdoctoral fellow in the lab of Rudolf Jaenisch at the Whitehead Institute for Biomedical Research/Massachusetts Institute of Technology. He joined the Stanford faculty in 2008.

Tracy Young-Pearse

Tracy Young-Pearse, PhD

Tracy Young-Pearse is an associate professor in the Ann Romney Center for Neurologic Diseases at Brigham and Women’s Hospital and co-director of the Nervous System Diseases Program at the Harvard Stem Cell Institute. Her lab uses human stem cells to study the functions of genes involved in neurodegenerative and neurodevelopmental diseases. She received her undergraduate degree from Skidmore College and went on to earn her PhD in genetics at Harvard Medical School, where she worked in the lab of Constance Cepko. She completed her postdoctoral fellowship under the mentorship of Dennis Selkoe before starting her own lab in 2010.

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