Next Generation Human Disease Models in Neuroscience
Organized by Lorenz Studer, MD and Marius Wernig, MD, PhD
September 27, 11 a.m.–5 p.m. EDT
Click on each session title to reveal its description or download a one page version of the agenda here.
Session 1: Basics and Bottlenecks — New Developments and Challenges
Speakers: Kristin Baldwin
and Lorenz Studer
Time: 11 a.m. – noon EDT
Reprogramming methods, including induced pluripotent stem cells (iPSCs) and organoid cultures, have opened new doors into modeling human disease in the culture dish. Lorenz Studer and Kristin Baldwin will discuss new developments in cellular reprogramming methods and technologies, while also addressing the challenges and opportunities that lie ahead for the field.
Session 2: Novel Human Cell Models of the Developing Human Cortex
Speakers: Guo-li Ming
and Arnold Kriegstein
Time: 12:15 – 1:15 EDT
Three-dimensional (3D) organoid cultures from human induced pluripotent stem cells enable a comprehensive study of the development and cytoarchitecture of the human brain. In this session, Arnold Kriegstein will discuss the cellular diversity of cerebral organoids and the effect of metabolic stress on organoid cultures. Then, Guo-li Ming will share the advances her lab has made in producing brain-region specific organoids and furthering their maturation to model human brain development.
Session 3: Investigating Pathomechanisms of Neurodevelopmental and Neuropsychiatric Diseases Using Human Cell Models
Speakers: Silvia Cappello
and Marius Wernig
Time: 1:30 – 2:30 EDT
Cellular reprogramming methods allow for the creation of human disease models that more closely mimic the molecular and cellular mechanisms of neurodevelopmental and neuropsychiatric disorders than mouse homologues. In this session, Silvia Capello will discuss how the use of human-derived cerebral organoids allows her lab to investigate the mechanisms of neuronal migration during development. Then, Marius Wernig will explore how his lab is using reprogrammed patient donor cells to study the role of a mutation in a synaptic cell-adhesion molecule in autism spectrum disorders.
Session 4: Therapeutic Discovery for Neurodegenerative Disorders Using Pluripotent Stem Cell-Based Phenotypic Screening
Speakers: Justin Ichida
and Paul Tesar
Time: 2:45 – 3:45 EDT
Stem cell and reprogramming technologies provide unprecedented access to disease-relevant cells and tissues to create in vitro models of human neurodegenerative diseases. These cellular technologies enable large-scale, in vitro screening of drug-like compounds to identify potential therapeutics. Justin Ichida will discuss his lab’s work on screening for drugs that enhance the survival of motor neurons for diseases like amyotrophic lateral sclerosis (ALS), and Paul Tesar will share his lab’s work on screening for drugs that stimulate regeneration of myelin in disease like multiple sclerosis.
Session 5: Using iPSC Techniques to Study the Genetics of Neurodegenerative Disorders
Speakers: Hideyoku Okano
and Tracy Young-Pearse
Time: 4 – 5 EDT
Induced pluripotent stem cells generated from patient populations have become a key tool for understanding the genetics of neurodegenerative disorders such as ALS and Alzheimer’s disease (AD). Hideyuki Okano will discuss how his lab classifies the genomic and phenotypic characteristics of iPSCs generated from patients with sporadic ALS. Then, Tracy Young-Pearse will present her lab’s work on generating iPSC lines from deeply phenotyped cohorts to study late-onset AD.
Data Blitz Sessions
This virtual conference will include short data blitz videos accessible to attendees. These videos feature neuroscientists describing their research applying computer vision to neuroscience problems. The videos are available on demand, so you can watch them throughout the live day or after the conference.
Data blitz videos will be provided by: Shan Bian, Fred Etoc, Faranak Fattahi, Kosuke Funato & Ryan Smith, Evangelos Kiskinis, Hiroko Nobuta, and Pedro Rifes
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